Aricept (Donepezil), is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer‘s disease where it is used to increase cortical acetylcholine. Donepezil is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, donepezil’s effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact.

It turns out  generally that whether a history of head trauma or injury is a cause of Alzheimer’s disease of the symptoms of Alzheimer’s disease is not certain or indeed uncertain by itself.

It can be pointed out that some published studies of repute suggest that head trauma that results in what may or should be considered  a loss of consciousness is a definite risk factor and factors into the risks of a patient developing Alzheimer’s disease.

Thus people who expose themselves to repeated head trauma or injury , such as you might find in the classic cases of boxers such as Muhammed Ali, who developed serious Parkinson’s disease – perhaps as a result of his boxing career, or football players can be said to be , as a result , at a higher risk of developing Alzheimer’s disease as opposed to if they had not followed their chosen career path or paths.  Regardless of whether or not actual Alzheimer’s disease progresses as a result of the specific person’s health and mental and memory cognitive skill levels-  many such people who are continually exposed to head trauma and head trauma injuries  do go later to more often than the general population , have incidences of difficulties of memory , concentration, speech  and other brain function difficulties higher than the general population overall .

Dimebon Alzheimer?s Disease

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