Dimebon Dimebolin Information Availability » Russia

Latrepirdine

admin — Fri, 13 Jan 2012 02:09:35 +0000

Latrepirdine ( also known as dimebolin and sold as Dimebon), is an antihistamine drug which has been used clinically in Russia since 1983.

Research is continuing in both Russia and western nations into potential applications as a neuroprotective drug to combat Alzheimer’s disease and, possibly, as a nootropic as well.However, a Phase III clinical trial for Alzheimer’s disease (AD) treatment failed to show any benefit. Three other AD trials continue. Dimebon failed in the phase III trial for Huntington disease.

Uses

Latrepirdine is an orally-active small molecule compound that has been shown to inhibit brain cell death in animal models of Alzheimer’s disease and Huntington’s disease. Research suggests that it may also have cognition-enhancing effects in healthy individuals, in the absence of neurodegenerative disease pathology. However, because of negative results in human clinical trials, the drug remains unlicensed for any neurodegenerative condition.

http://en.wikipedia.org/wiki/Latrepirdine

Park Mazda

Puerto Morelos Dental Clinic

Dimebon Dimebolin Information Availability

Dimebolin

admin — Mon, 26 Dec 2011 01:37:20 +0000

Description

Dimebolin is an orally-available drug, approved in Russia for use as a non-selective antihistamine, that has shown promise in the treatment of neurodegenerative diseases, including Alzheimer’s ^1,2 and Huntington’s disease.³ In addition to reported activity in preventing the onset and progression of disease by being neuroprotective, dimebolin appears to promote clinical improvement by increasing cognitive function.^4,2 At the cellular level, dimebolin appears to have diverse effects, inhibiting the neurotoxic action of ?-amyloid and blocking L-type calcium channels,⁵ inhibiting NMDA-type glutamate receptors,⁶ and preventing mitochondrial leakage.⁷

Synonyms	Dimebon™
Formal Name	2,?3,?4,?5-?tetrahydro-?2,?8-?dimethyl-?5-?[2-?(6-?methyl-?3-?pyridinyl)ethyl]-?1H-?pyrido[4,?3-?b]indole
CAS Number	3613-73-8
Molecular Formula	C₂₁H₂₅N₃
Formula Weight	319.4
Formulation	A crystalline solid
Purity	?98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	CC1=CC=C(N(CCC2=CC=C(C)?N=C2)?C3=C4CN(C)?CC3)?C4=

Dimebon Dimebolin Information Availability

admin — Sun, 15 Mar 2009 13:47:00 +0000

Dimebom is a new pharmaceutical treatment alternative for patients suffering from Alzheimer’s Disease. Dimebon is an older medication that has recently been discovered to be most helpful in treating patients with Alzheimer’s disease. Dimebom (the actual drug is known chemically as Dimebolin) is an older Russian antihistamine drug. It was popularly used in Russia as an antihistamine for hayfever, allergies and the like. In fact the drug was sold as an easy to obtain antihistamine – sold over the counter without a prescription.

Dimebom is currently in clinical trials in the United States by a company named Medivation . The website for Medivation, the pharmaceutical company involved with the clinical development and testing of Dimebom in the United States? Can be found at link www.medivation.com . To learn more about Medivation’s clinical trials of Dimebom the link is

http://www.medivation.com/pipeline_dimebontrials.html#p3

For more information on CONNECTION study locations, eligibility and enrollment, please visit www.connectionstudy.com or call toll-free 1-877-888-6386

At this point in time Dimebom is not available in any manner to Alzheimer Patients or their families, outside of the study material afforded by the Medivation Company and the Medivation clinical trials themselves.

Dimebon Alzheimer?s Disease

http://www.dimebonalzheimers.com

Diembon Dimebolin Summary Referenced Information Discovery Magazine Online

admin — Wed, 11 Feb 2009 16:16:30 +0000

The second drug, Dimebon, is an allergy drug used in Russia 20 years ago. A Lancet [subscription required] article in July reported that over 26 weeks of treatment, Dimebon significantly improved memory, thinking, and overall functioning in 68 Alzheimer?s patients, compared with a 66-member control group. Although researchers don?t know exactly how Dimebon does this, it may work by protecting mitochondria?the powerhouses of cells?from injury, says Rachelle Doody, the study?s lead author and a neurology professor at Baylor College of Medicine in Houston. A phase 3 trial for the drug began recruiting participants in June.

reference:? http://discovermagazine.com/2009/jan/018

Dimebon Dimebolin Information Availability

admin — Wed, 14 Jan 2009 14:10:05 +0000

Dimebom is a new pharmaceutical treatment alternative for patients suffering from Alzheimer’s Disease

Dimebon is an older medication that has recently been discovered to be most helpful in treating patients with Alzheimer’s Disease

Dimebon ( the actual drug is known chemically as Dimebolin) is an older Russian antihistamine drug. It was popularly used in Russia as an antihistamine for hayfever , allergies and the like. In fact the drug was sold as an easy to obtain antihistamine - sold over the counter without a prescription.

Dimebon is currently in clinical trials in the United States by a company named Medivation . The website for Medivation company can be found at http://www.medivation.com/

Dimebon and the clinical trial information of Medivation can be found at this link on the internet

http://www.medivation.com/pipeline_dimebontrials.html

At this point in time Dimebon is not available in any manner outside of the study material afforded by the Medivation company and the Medivation clinical trials themselves.

Dimebon Alzheimer’s Disease

http://www.dimebonalzheimers.com